Investigation of Colistin Heteroresistance Among Acinetobacter baumannii Isolates
نویسندگان
چکیده
منابع مشابه
Heteroresistance to colistin in multidrug-resistant Acinetobacter baumannii.
Multidrug-resistant Acinetobacter baumannii has emerged as a significant clinical problem worldwide and colistin is being used increasingly as "salvage" therapy. MICs of colistin against A. baumannii indicate its significant activity. However, resistance to colistin in A. baumannii has been reported recently. Clonotypes of 16 clinical A. baumannii isolates and ATCC 19606 were determined by puls...
متن کاملGlobal Epidemiology on Colistin Resistant Acinetobacter baumannii
While colistin remains a last resort agent to treat multi-drug resistant Acinetobacter baumannii, resistance to colistin has been reported throughout the world. The resistance has been attributed to mutations in lipid A biosynthesis genes and point mutation in PmrAB-two component response regulator and sensor kinase system. The emergence of plasmid mediated colistin resistance (mcr-1), in multi...
متن کاملColistin-resistant Acinetobacter baumannii: beyond carbapenem resistance.
BACKGROUND With an increase in the use of colistin methansulfonate (CMS) to treat carbapenem-resistant Acinetobacter baumannii infections, colistin resistance is emerging. METHODS Patients with infection or colonization due to colistin-resistant A. baumannii were identified at a hospital system in Pennsylvania. Clinical data were collected from electronic medical records. Susceptibility testi...
متن کاملPrevalence of hypermutators among clinical Acinetobacter baumannii isolates
OBJECTIVES The objectives of this study were to study the presence of mutators in a set of Acinetobacter baumannii isolates and to explore whether there is a correlation between mutation rates and antibiotic resistance. METHODS The variation in mutation rate was evaluated for 237 clinical A. baumannii isolates by determining the frequency of their mutation to rifampicin resistance. For each i...
متن کاملHeteroresistance to cephalosporins and penicillins in Acinetobacter baumannii.
Heteroresistance to antimicrobial agents may affect susceptibility test results and therapeutic success. In this study, we investigated heteroresistance to cephalosporins and penicillins in Acinetobacter baumannii, a major pathogen causing nosocomial infections. Two A. baumannii isolates exhibited heteroresistance to ampicillin-sulbactam, ticarcillin-clavulanic acid, cefepime, and cefpirome, sh...
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ژورنال
عنوان ژورنال: ANKEM DERGİSİ
سال: 2019
ISSN: 1301-3114
DOI: 10.5222/ankem.2019.114